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Saturday, September 29, 2012

Sodium Ascorbate Injection

Pronunciation: SO-dee-uhm a-SKOR-bate
Generic Name: Sodium Ascorbate
Brand Name: Cenolate

Sodium Ascorbate Injection is used for:

Treating and preventing low levels of vitamin C. It may also be used for other conditions as determined by your doctor.

Sodium Ascorbate Injection is a vitamin. It works by supplementing vitamin C, which is used in many functions in the body.

Do NOT use Sodium Ascorbate Injection if:

you are allergic to any ingredient in Sodium Ascorbate Injection or to another sulfite

Contact your doctor or health care provider right away if any of these apply to you.

Before using Sodium Ascorbate Injection:

Some medical conditions may interact with Sodium Ascorbate Injection. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have asthma, diabetes, or kidney problems, including if you are on dialysis

if you have glucose-6-phosphate dehydrogenase deficiency, a high iron level in the blood, anemia (eg, sickle cell, sideroblastic, thalassemia), or kidney stones

Some MEDICINES MAY INTERACT with Sodium Ascorbate Injection. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Sodium Ascorbate Injection

Disulfiram because its effectiveness may be decreased by Sodium Ascorbate Injection

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sodium Ascorbate Injection may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Sodium Ascorbate Injection:

Use Sodium Ascorbate Injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Sodium Ascorbate Injection is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Sodium Ascorbate Injection at home, a health care provider will teach you how to use it. Be sure you understand how to use Sodium Ascorbate Injection. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

Do not use Sodium Ascorbate Injection if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

If you miss a dose of Sodium Ascorbate Injection, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Sodium Ascorbate Injection.

Important safety information:

Do not take large doses of vitamins (megadoses or megavitamin therapy) while you use Sodium Ascorbate Injection unless your doctor tells you to.

Some of these products contain sulfites. Sulfites may cause an allergic reaction in some patients (eg, asthma patients). If you have ever had an allergic reaction to sulfites, ask your pharmacist if your product has sulfites in it.

Sodium Ascorbate Injection has aluminum in it. Before you start any new medicine, check the label to see if it has aluminum in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Diabetes patients - Sodium Ascorbate Injection may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.

Use Sodium Ascorbate Injection with caution in the ELDERLY; they may be more sensitive to its effects, especially increased blood levels of aluminum.

Sodium Ascorbate Injection should be used with extreme caution in NEWBORNS or INFANTS. It may cause serious nervous system problems and other side effects.

PREGNANCY and BREAST-FEEDING: It is not known if Sodium Ascorbate Injection can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sodium Ascorbate Injection while you are pregnant Sodium Ascorbate Injection is found in breast milk. If you are or will be breast-feeding while you use Sodium Ascorbate Injection, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Sodium Ascorbate Injection:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning, pain, stinging, or swelling at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bone pain; mental or mood changes; muscle weakness; severe or persistent diarrhea.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Sodium Ascorbate side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Sodium Ascorbate Injection:

Store Sodium Ascorbate Injection in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Store away from heat, moisture, and light. Keep Sodium Ascorbate Injection out of the reach of children and away from pets.

General information:

If you have any questions about Sodium Ascorbate Injection, please talk with your doctor, pharmacist, or other health care provider.

Sodium Ascorbate Injection is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Sodium Ascorbate Injection. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Sodium Ascorbate resources

Sodium Ascorbate Side Effects (in more detail)
Sodium Ascorbate Use in Pregnancy & Breastfeeding
Sodium Ascorbate Drug Interactions
Sodium Ascorbate Support Group
0 Reviews for Sodium Ascorbate - Add your own review/rating

Compare Sodium Ascorbate with other medications

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Saturday, September 22, 2012

Succinylcholine Chloride

Class: Neuromuscular Blocking Agents
VA Class: MS300
CAS Number: 71-27-2
Brands: Anectine, Quelicin

Rhabdomyolysis with Hyperkalemia

Risk of acute rhabdomyolysis with hyperkalemia followed by ventricular arrhythmias, cardiac arrest, and death in apparently healthy children and adolescents who subsequently were found to have undiagnosed skeletal muscle myopathy (e.g., Duchenne’s muscular dystrophy).^a

Use in children and adolescents should be reserved for those undergoing emergency intubation,^a those in whom an airway should be secured immediately (e.g., those with laryngospasm, difficult airway, or full stomach),^a or those in whom a suitable vein is not accessible and IM administration is needed.^b (See Pediatric Use under Cautions.)

Experience of Clinician

Should be administered only by individuals experienced in the use of neuromuscular blocking agents.^a

Introduction

Depolarizing neuromuscular blocking agent.^a

Uses for Succinylcholine Chloride

Skeletal Muscle Relaxation

Production of skeletal muscle relaxation during procedures of short duration (e.g., endotracheal intubation, endoscopic examinations, electrically or pharmacologically induced convulsive therapy) after general anesthesia has been induced;^a ^b neuromuscular blocking agent of choice for procedures lasting <3 minutes.^b

Drug of choice for skeletal muscle relaxation during orthopedic manipulations.^b (See Orthopedic Precautions under Cautions.)

Facilitation of endotracheal intubation;^a generally preferred in emergency situations where rapid intubation is required.^b

Treatment to increase pulmonary compliance during assisted or controlled respiration.^a

Succinylcholine Chloride Dosage and Administration

General

Carefully adjust dosage according to individual requirements and response.^a

To avoid patient distress, generally administer only after unconsciousness has been induced;^a however, may administer before unconsciousness has been induced in emergency situations.^a

To evaluate patient’s ability to metabolize succinylcholine and to determine individual patient sensitivity and recovery time, a test dose may be administered to spontaneously breathing patient after anesthesia has been induced.^a ^b (See Test Dose under Dosage and Administration.)

Assess neuromuscular blockade and recovery in patients undergoing anesthesia;^c careful assessment with a peripheral nerve stimulator is recommended during continuous IV infusions to monitor the degree of neuromuscular blockade, to detect the development of phase II block, and to minimize the possibility of overdosage.^a

Administration

Administer IV or IM.^a IV administration is preferred; if necessary, administer IM in infants or other patients in whom a suitable vein is not accessible.^a

For specific procedures and techniques of administration, consult specialized references.^b

IV Administration

For solution and drug compatibility information, see Compatibility under Stability.

For prolonged procedures, administer by continuous IV infusion (preferably) or intermittent IV injection.^a

Multiple fractional doses generally should not be used; repeated fractional doses and, to a lesser extent, continuous infusion, may lead to tachyphylaxis.^a ^b (See Prolonged or Repeated Administration under Cautions.)

Dilution

For continuous IV infusion, dilute succinylcholine chloride to a concentration of 1–2 mg/mL in 5% dextrose injection, 5% dextrose and 0.9% sodium chloride injection, 0.9% sodium chloride injection, or (1/6) M sodium lactate injection.^a ^b 1 mg/mL usually is used for optimum dosage control;^a 2 mg/mL may be preferred if amount of fluid should be limited.^b

Do not admix with alkaline solutions.^a (See Compatibility under Stability.)

Rate of Administration

Administer dose over 10–30 seconds for short procedures.^b

Individualize rate of continuous IV infusion.^a

IM Administration

Administer by deep IM injection, preferably high into deltoid muscle.^a ^b

Dosage

Available as succinylcholine chloride; dosage expressed in terms of the salt.^a

Pediatric Patients

Skeletal Muscle Relaxation

IV

Infants and small children: 2 mg/kg.^a

Older children and adolescents: 1 mg/kg.^a

If necessary, administer additional doses in accordance with patient’s response.^a ^b

Continuous IV infusions considered unsafe in neonates and children.^b (See Pediatric Use under Cautions.)

IM

Infants and older children: up to 3–4 mg/kg (maximum 150 mg).^a

Adults

Skeletal Muscle Relaxation

Test Dose

0.1 mg/kg (approximately 5–10 mg).^b If test dose produces moderate muscle relaxation, 20-mg dose probably sufficient for short procedures; if test dose produces minimum relaxation, 30 mg probably needed.^b

Dosage for Procedure

For short procedures, usual dose is 0.6 mg/kg (range 0.3–1.1 mg/kg);^a if necessary, administer additional doses in accordance with patient’s response.^b (See Onset and also Duration under Pharmacokinetics.)

For prolonged procedures, usual dosage is 2.5 mg/minute by continuous IV infusion; adjust rate (range: 0.5–10 mg/minute) depending on patient’s response and requirements.^a ^b Alternatively, administer by intermittent IV injection: initially 0.3–1.1 mg/kg, followed by additional doses of 0.04–0.07 mg/kg as necessary to maintain adequate muscle relaxation. (see IV Administration under Dosage and Administration.)^a (See Onset and also Duration under Pharmacokinetics.)

Up to 3–4 mg/kg (maximum 150 mg).^a (See Onset and also Duration under Pharmacokinetics.)

Prescribing Limits

Pediatric Patients

Skeletal Muscle Relaxation

IM

Maximum total dose 150 mg.^a

Adults

Skeletal Muscle Relaxation

IM

Maximum total dose 150 mg.^a

Special Populations

Geriatric Patients

Careful dosage selection recommended due to possible age-related decrease in hepatic, renal, and/or cardiac function and concomitant disease and drug therapy; initiate therapy at low end of dosage range.^b

Patients with Reduced Plasma Cholinesterase Activity

Administer small test dose (5–10 mg) or cautiously administer 1-mg/mL solution by slow IV infusion.^a (See Patients Homozygous for the Atypical Plasma Cholinesterase Gene and also Reduced Plasma Cholinesterase Activity, under Cautions.)

Cautions for Succinylcholine Chloride

Contraindications

Personal or familial history of malignant hyperthermia.^a

Myopathies associated with elevated serum creatine kinase (CK, CPK) values.^a ^b

Upper motor neuron injury, multiple trauma, extensive or severe burns, extensive denervation of skeletal muscle because of CNS disease or injury.^a (See Hyperkalemia under Cautions.)

Known hypersensitivity to succinylcholine or any ingredient in the formulation.^a

Warnings/Precautions

Warnings

Respiratory Effects

Potential for severely compromised respiratory function and respiratory paralysis.^a Complete or prolonged respiratory paralysis frequently occurs at doses >1 mg/kg.^b

Possible transient apnea with single doses ≤30 mg or infusion rates of 2.5 mg/minute; however, spontaneous respiration usually returns in a few seconds or a maximum of 4 minutes.^b Institute oxygen if spontaneous respiration does not occur promptly.^b Avoid hyperventilation (may prolong apnea).^b

Should be used only by individuals experienced in the use of neuromuscular blocking agents and in the maintenance of an adequate airway and respiratory support.^a Facilities and personnel necessary for intubation, administration of oxygen, and assisted or controlled respiration should be immediately available.^a

Use with caution in patients with pulmonary impairment or respiratory depression.^c

Patients Homozygous for the Atypical Plasma Cholinesterase Gene

Possible prolonged respiratory depression and muscle relaxation in patients homozygous for the atypical plasma cholinesterase gene.^a ^b Use with extreme caution, if at all, in such patients.^a (See Patients with Reduced Plasma Cholinesterase Activity under Dosage and Administration.)^a

Hyperkalemia

Potential for acute rhabdomyolysis with hyperkalemia.^a (See Boxed Warning and also Pediatric Use under Cautions.)

Possible severe hyperkalemia resulting in serious cardiac arrhythmias or cardiac arrest in patients with upper motor neuron injury, multiple trauma, extensive or severe burns, or extensive denervation of skeletal muscle because of CNS disease or injury; use is contraindicated in these patients.^a Risk of hyperkalemia depends on extent and location of the injury, increases over time, usually peaks 7–10 days after the injury,^a and can persist for >6 months after neural injury.^b

Use with extreme caution in patients with preexisting hyperkalemia or those at increased risk of hyperkalemia (e.g., those with paraplegia, chronic abdominal infection, tetanus, subarachnoid hemorrhage, degenerative or dystrophic neuromuscular disease, or conditions that may cause degeneration of central and peripheral nervous systems).^a ^b

Use with extreme caution in patients receiving quinidine or cardiac glycosides or those with suspected cardiac glycoside toxicity (due to potential for hyperkalemia).^b

Malignant Hyperthermia

Possible fatal malignant hyperthermia; manifested by a rapid, profound elevation in body temperature and sometimes extreme muscular rigidity.^a Risk increases with concomitant administration of inhalation anesthetics.^a (See Specific Drugs under Interactions.)

If malignant hyperthermia occurs, discontinue all anesthetic agents and initiate IV dantrolene therapy^a in conjunction with supportive measures (e.g., administering oxygen, treating metabolic acidosis, instituting cooling procedures); maintain urinary output and monitor serum electrolytes.^c

Bradycardia

Possible profound bradycardia resulting from vagal stimulation and accompanied by hypotension and cardiac arrhythmias (e.g., nodal rhythms, extrasystoles, bigeminy, AV block, cardiac arrest).^a ^b

Occurs most commonly with repeated administration^a and in children^a (see Pediatric Use under Cautions).

Prior administration of atropine may inhibit vagal stimulation and reduce occurrence of bradycardia.^a ^b

Use with extreme caution in patients with electrolyte disturbances, those receiving quinidine or cardiac glycosides, or those with suspected cardiac glycoside toxicity.^b

Ophthalmic Effects

Possible increased intraocular pressure.^a

Use not recommended in patients with angle-closure glaucoma or penetrating eye injuries.^a Use with extreme caution, if at all, during ocular surgery; nondepolarizing neuromuscular blocking agent may be preferred.^b

Sensitivity Reactions

Hypersensitivity Reactions

Hypersensitivity reactions, including anaphylaxis, reported rarely.^a

General Precautions

Prolonged or Repeated Administration

Possible tachyphylaxis and prolonged and difficult-to-reverse apnea; multiple fractional doses alone generally should not be used.^a

Possible prolonged neuromuscular blockade due to change of the characteristic depolarizing neuromuscular block (phase I block) to a phase II block.^a

To reverse phase II block, administer a cholinesterase inhibitor (e.g., neostigmine, pyridostigmine, edrophonium), in conjunction with an antimuscarinic (e.g., atropine, glycopyrrolate) to prevent disturbances in cardiac rhythm.^a Use a peripheral nerve stimulator to confirm change to phase II block prior to administering cholinesterase inhibitor.^a

To ensure complete hydrolysis of succinylcholine by plasma pseudocholinesterase prior to administration of cholinesterase inhibitor, do not attempt reversal unless spontaneous recovery of muscle twitch has been observed for ≥20 minutes and has plateaued, with further recovery from neuromuscular blockade occurring slowly.^a (See Actions.)

Intracranial Pressure

Possible slight, transient increase in intracranial pressure.^a

Intragastric Pressure

Possible increased intragastric pressure secondary to fasciculation of abdominal muscles; potential for regurgitation and possible aspiration of stomach contents.^a May be prevented by prior administration of small dose of nondepolarizing neuromuscular blocking agent.^b

Reduced Plasma Cholinesterase Activity

Possible prolonged respiratory depression and muscle relaxation in patients with reduced plasma cholinesterase activity.^a ^b

Plasma cholinesterase activity may be reduced in patients heterozygous for the atypical pseudocholinesterase gene, pregnant women, and patients with severe hepatic or renal disease, malnutrition, infections, severe anemia, severe dehydration, burns, cancer, collagen diseases, myxedema, decompensated heart disease, peptic ulcer disease, or abnormal body temperature.^a ^b (See Patients Homozygous for the Atypical Plasma Cholinesterase Gene under Cautions and also see Specific Drugs under Interactions.)

Some clinicians recommend determining plasma pseudocholinesterase activity prior to administration.^b

Administer with extreme caution and in reduced doses, if at all, in patients with abnormally low pseudocholinesterase concentrations.^b If low concentrations are suspected, a test dose or cautious continuous IV infusion may be administered. (See Test Dose and also Patients with Reduced Plasma Cholinesterase Activity, under Dosage and Administration.)

Treat apnea or prolonged muscle paralysis with controlled respiration.^a Administration of fresh whole blood or plasma may restore pseudocholinesterase concentrations.^b

Electrolyte Disturbances

Possible prolonged neuromuscular blockade in patients with electrolyte disturbances (e.g., hypocalcemia, hypokalemia).^a Use with caution.^c (See Hyperkalemia and also Bradycardia under Cautions.)

Histamine Release

Possible histamine release; manifestations associated with histamine release (e.g., flushing, erythema, pruritus, urticaria, wheal formation, wheezing, bronchospasm, hypotension) uncommon at usual dosages.^a ^b

Orthopedic Precautions

Use with caution in patients with fractures, dislocations, or muscular spasms; initial muscle fasciculation may cause additional trauma.^a

Specific Populations

Pregnancy

Category C.^a (See Reduced Plasma Cholinesterase Activity under Cautions.)

Lactation

Not known whether succinylcholine is distributed into milk.^a Caution advised if succinylcholine is used.^a

Pediatric Use

Possible acute rhabdomyolysis with hyperkalemia followed by ventricular arrhythmias, cardiac arrest, and death; usually occurs in males ≤8 years of age.^a If cardiac arrest occurs, initiate treatment for hyperkalemia.^a Prolonged or extraordinary resuscitative measures may be required.^a Use in children and adolescents should be reserved for those undergoing emergency intubation,^a those in whom an airway should be secured immediately (e.g., those with laryngospasm, difficult airway, or full stomach),^a or those in whom a suitable vein is not accessible and IM administration is needed.^b

Possible profound bradycardia or, rarely, asystole when administered by rapid IV injection.^a ^b Risk increases with repeated doses; consider pretreatment with atropine.^a

Possible risk of malignant hyperthermia; institute appropriate therapy if malignant hyperthermia occurs.^a Rarely, myoglobinuria and myoglobinemia have been reported in conjunction with malignant hyperthermia and muscle rigidity.^b Continuous IV infusions are considered unsafe in neonates and children due to risk of malignant hyperthermia.^b (See Malignant Hyperthermia under Cautions.)

Large amounts of benzyl alcohol (i.e., 100–400 mg/kg daily) have been associated with toxicity in neonates;^e ^f ^g ^h ⁱ ^j some succinylcholine chloride injections may contain benzyl alcohol 10 mg/mL.^b

Geriatric Use

Use with caution due to greater frequency of decreased hepatic, renal, and/or cardiac function and of concomitant disease and drug therapy observed in the elderly.^a Titrate dosage carefully.^b

Hepatic Impairment

Possible decreased plasma cholinesterase activity in patients with severe hepatic impairment;^a use with caution.^c (See Elimination: Special Populations, under Pharmacokinetics.)

Renal Impairment

Possible decreased plasma cholinesterase activity in patients with severe renal impairment.^a Possible accumulation of succinylmonocholine, resulting in prolonged apnea.^b Use with caution.^c

Common Adverse Effects

Postoperative pain, jaw rigidity, excessive salivation, rash, hypotension.^a

Interactions for Succinylcholine Chloride

Specific Drugs

Drug	Interaction	Comments
β-Adrenergic blocking agents	Possible increased neuromuscular blockade^a	Use with caution^b
Anesthetics, inhalation (e.g., desflurane, isoflurane)	Possible increased neuromuscular blockade^a	Use with caution^b
Antiarrhythmic agents (lidocaine, procainamide, quinidine)	Possible increased neuromuscular blockade^a	Use with caution^b
Anti-infective agents (aminoglycosides, bacitracin, clindamycin, lincomycin, polymyxins, tetracyclines)	Possible increased neuromuscular blockade^a ^c	Use with caution^b
Antimalarials (chloroquine, quinine)	Possible increased neuromuscular blockade^a	Use with caution^b
Aprotinin	Possible increased neuromuscular blockade^a	Use with caution^b
Cholinesterase inhibitors (demecarium, isofluorophate, organophosphate insecticides)	Decreased activity of plasma pseudocholinesterase^b	Use with caution^b
Contraceptives, oral	Possible decreased plasma cholinesterase activity and increased neuromuscular blockade^a	Use with caution^b
Corticosteroids	Possible decreased plasma cholinesterase activity and increased neuromuscular blockade^a	Use with caution^b
Cyclophosphamide	Possible decreased plasma cholinesterase activity and increased neuromuscular blockade^a ^b	Use with caution^b
Lithium	Possible increased neuromuscular blockade^a	Use with caution^b
Magnesium salts	Possible increased neuromuscular blockade^a	Use with caution^b
MAO inhibitors	Possible decreased plasma cholinesterase activity and increased neuromuscular blockade^a	Use with caution^b
Metoclopramide	Possible increased neuromuscular blockade^a	Use with caution^b
Neostigmine	Possible decreased plasma cholinesterase activity and increased neuromuscular blockade^b	Use with caution^b
Oxytocin	Possible increased neuromuscular blocking effect^a	Use with caution^b
Phenothiazines	Possible decreased plasma cholinesterase activity and increased neuromuscular blockade^a	Use with caution^b
Procaine	Potential decreased metabolism of succinylcholine^b	Concurrent IV administration not recommended^b
Skeletal muscle relaxants (pancuronium)	Possible decreased plasma cholinesterase activity and increased neuromuscular blockade^b	Use with caution^b
Terbutaline	Possible increased neuromuscular blockade^a	Use with caution^b
Thiotepa	Possible decreased plasma cholinesterase activity and increased neuromuscular blockade^a ^b	Use with caution^b

Succinylcholine Chloride Pharmacokinetics

Absorption

Bioavailability

Poorly absorbed from the GI tract.^c

Onset

Following IV administration, onset is rapid; complete muscle relaxation occurs within 0.5–1 minute following 10- to 30-mg dose.^b

Following IM administration, onset occurs in about 2–3 minutes.^b

Duration

Following IV administration, duration of action is short (about 2–3 minutes following 10- to 30-mg dose; effects gradually dissipate within 10 minutes).^b Duration of action may be prolonged when administered as continuous IV infusion or in fractional doses.^b

Following IM administration, duration of action ranges from 10–30 minutes.^b

Special Populations

Duration of action is prolonged in patients with low plasma pseudocholinesterase concentrations.^b

Distribution

Extent

Crosses the placenta in small amounts.^a

Elimination

Metabolism

Rapidly hydrolyzed by plasma pseudocholinesterase to succinylmonocholine and then more slowly to succinic acid and choline.^a

Elimination Route

Excreted in urine as active and inactive metabolites and small amounts of unchanged drug.^a ^b ^c

Special Populations

Severe hepatic impairment may decrease plasma pseudocholinesterase activity, resulting in increased duration of action due to reduced metabolism.^c

In patients with renal impairment, possible decreased plasma pseudocholinesterase activity and possible accumulation of succinylmonocholine.^b

Stability

Storage

Parenteral

Injection

2–8°C.^a Multiple-dose vials stable up to 14 days at room temperature.^a

Compatibility

For information on systemic interactions resulting from concomitant use, see Interactions.

Parenteral

May be incompatible with alkaline solutions with pH >8.5 (e.g., barbiturate solutions).^a

Solution Compatibility^HID

Compatible
Dextran 6% in dextrose 5%
Dextran 6% in sodium chloride 0.9%
Dextrose–Ringer’s injection combinations
Dextrose–Ringer’s injection, lactated, combinations
Dextrose 5% in Ringer’s injection, lactated
Dextrose–saline combinations
Dextrose 5% in sodium chloride 0.9%
Dextrose 2.5, 5, or 10% in water
Fructose 10% in sodium chloride 0.9%
Fructose 10% in water
Invert sugar 5 and 10% in sodium chloride 0.9%
Invert sugar 5 and 10% in water
Ionosol products
Ringer’s injection
Ringer’s injection, lactated
Sodium chloride 0.45 or 0.9%
Sodium lactate (1/6) M

Drug Compatibility

Admixture CompatibilityHID
Compatible
Amikacin sulfate
Isoproterenol HCl
Meperidine HCl
Methyldopate HCl
Morphine sulfate
Norepinephrine bitartrate
Scopolamine HBr
Incompatible
Pentobarbitol sodium
Sodium bicarbonate
Thiopental sodium

Y-Site CompatibilityHID
Compatible
Etomidate
Heparin sodium with hydrocortisone sodium succinate
Hetastarch in lactated electrolyte injection (Hextend)
Potassium chloride
Propofol
Vitamin B complex with C
Incompatible
Thiopental sodium

ActionsActions

Produces skeletal muscle relaxation by causing a decreased response to acetylcholine (ACh) at the myoneural (neuromuscular) junction of skeletal muscle.^c

Exhibits high affinity for ACh receptor sites and produces depolarization of motor end-plate at myoneural junction, resulting in transient twitching or fasciculation of skeletal muscles, followed by muscle paralysis (phase I block).^c

Prolonged or repeated administration results in gradual and variable transition to phase II block, which resembles nondepolarizing block.^a

Phase I block is potentiated by cholinesterase inhibitors and can be reversed by nondepolarizing neuromuscular blocking agents; fully established phase II block can be reversed by cholinesterase inhibitors and potentiated by nondepolarizing agents.^c

Stimulates cardiac vagus and subsequently sympathetic ganglia.^c

Advice to Patients

Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.^a

Importance of informing clinician of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses (e.g., cardiovascular disease, neuromuscular disease).^a

Importance of informing patients of other important precautionary information.^a (See Cautions.)

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Succinylcholine Chloride
Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Parenteral	Injection	20 mg/mL*	Anectine (with methylparaben)	Sabex
			Quelicin (with and without preservatives)	Hospira
			Succinylcholine Chloride Injection (with benzyl alcohol 1%)	Organon
		100 mg/mL	Quelicin (preservative-free)	Hospira
	Sterile, for IV infusion	500 mg	Anectine Flo-Pack	GlaxoSmithKline
			Quelicin	Hospira
		1 g	Anectine Flo-Pack	GlaxoSmithKline
			Quelicin	Hospira

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions July 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

References

a. Baxter. Quelicin (succinylcholine chloride) injection prescribing information. Deerfield, IL: 1999 Mar.

b. AHFS Drug Information 2004. McEvoy GK, ed. Succinylcholine chloride. Bethesda, MD: American Society of Health-System Pharmacists; 2004:1315-7.

c. AHFS Drug Information 2004. McEvoy GK, ed. Neuromuscular blocking agents general statement. Bethesda, MD: American Society of Health-System Pharmacists; 2004:1303-6.

HID. Trissel LA. Handbook on injectable drugs. 14th ed. Bethesda, MD: American Society of Health-System Pharmacists; 2007:1511-3.

e. American Academy of Pediatrics Committee on Fetus and Newborn and Committee on Drugs. Benzyl alcohol: toxic agent in neonatal units. Pediatrics. 1983; 72:356-8. [IDIS 175725] [PubMed 6889041]

f. Anon. Benzyl alcohol may be toxic to newborns. FDA Drug Bull. 1982; 12(2):10-11.

g. Centers for Disease Control. Neonatal deaths associated with use of benzyl alcohol. MMWR Morb Mortal Wkly Rep. 1982; 31:290-1. [IDIS 150868] [PubMed 6810084]

h. Gershanik J, Boecler B, Ensley H et al. The gasping syndrome and benzyl alcohol poisoning. N Engl J Med. 1982; 307:1384-8. [IDIS 160823] [PubMed 7133084]

i. Menon PA, Thach BT, Smith CH et al. Benzyl alcohol toxicity in a neonatal intensive care unit: incidence, symptomatology, and mortality. Am J Perinatol. 1984; 1:288-92. [PubMed 6440575]

j. Anderson CW, Ng KJ, Andresen B et al. Benzyl alcohol poisoning in a premature newborn infant. Am J Obstet Gynecol. 1984; 148:344-6. [IDIS 181207] [PubMed 6695984]

More Succinylcholine Chloride resources

Succinylcholine Chloride Side Effects (in more detail)
Succinylcholine Chloride Use in Pregnancy & Breastfeeding
Succinylcholine Chloride Drug Interactions
Succinylcholine Chloride Support Group
0 Reviews for Succinylcholine Chloride - Add your own review/rating

Anectine Prescribing Information (FDA)

Anectine MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Succinylcholine Chloride with other medications

Anesthesia

Friday, September 21, 2012

Tiludronate

Pronunciation: TYE-loo-DROE-nate
Generic Name: Tiludronate
Brand Name: Skelid

Tiludronate is used for:

Treating adults with Paget disease. It may also be used for other conditions as determined by your doctor.

Tiludronate is a bisphosphonate. It works by slowing the resorption of bone and allowing new bone to be formed.

Do NOT use Tiludronate if:

you are allergic to any ingredient in Tiludronate

you have severe kidney problems

you are unable to stand or sit for at least 30 minutes

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tiludronate:

Some medical conditions may interact with Tiludronate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have esophagus problems (eg, Barrett esophagus, narrow or blocked esophagus), trouble swallowing, pain or burning with swallowing, or stomach or intestinal problems (eg, ulcers, inflammation)

if you have a history of kidney problems, heartburn, chest pain, or low blood calcium levels

Some MEDICINES MAY INTERACT with Tiludronate. However, no specific interactions with Tiludronate are known at this time.

Ask your health care provider if Tiludronate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tiludronate:

Use Tiludronate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Tiludronate is effective only if taken on an empty stomach. Do not take Tiludronate within 2 hours of eating or drinking.

Take Tiludronate by mouth with a full glass of water (6 to 8 oz/180 to 240 mL). Do not lie down for at least 30 minutes after you take Tiludronate.

If you are also taking calcium or iron supplements, vitamins, antacids containing calcium, aspirin, or indomethacin, they may interfere with the absorption of Tiludronate. Do not take Tiludronate within 2 hours of these medicines.

If you are also taking an antacid that has aluminum or magnesium in it, take it at least 2 hours after you take Tiludronate.

Continue to take Tiludronate even if you feel well. Do not miss any doses.

If you miss a dose of Tiludronate, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses on the same day.

Ask your health care provider any questions you may have about how to use Tiludronate.

Important safety information:

Tiludronate may cause drowsiness. This effect may be worse if you take it with alcohol or certain medicines. Use Tiludronate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Do not drink alcohol, smoke, or use other tobacco products while taking Tiludronate.

It is important to have enough calcium and vitamin D in your diet. Ask your doctor or pharmacist if you have questions about your diet or about taking dietary supplements such as calcium or vitamin D.

Talk to your doctor about weight-bearing exercises to increase the calcium density of your bones.

Tiludronate may cause jaw bone problems in some patients. Your risk may be greater if you have cancer, poor dental hygiene, or certain other conditions (eg, anemia, blood clotting problems, infections, dental problems). Your risk may also be greater if you use certain medicines or therapies (eg, chemotherapy, corticosteroids, radiation). Talk to your doctor about having a dental exam before you start to use Tiludronate. Ask your doctor any questions you may have about dental treatment while you use Tiludronate.

Tell your doctor or dentist that you take Tiludronate before you receive any medical or dental care, emergency care, or surgery.

Lab tests, including calcium levels, may be performed while you use Tiludronate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Tiludronate should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tiludronate while you are pregnant. It is not known if Tiludronate is found in breast milk. If you are or will be breast-feeding while you use Tiludronate, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Tiludronate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations; diarrhea; gas; nausea; stomach upset; stuffy nose; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; chest pain; difficulty swallowing; new, worsening, or severe heartburn; pain when swallowing; red, swollen, blistered, or peeling skin; severe bone, muscle, or joint pain; severe or persistent stomach pain; swelling of the hands or feet; swelling or pain in the jaw; throat pain or irritation; vision changes; vomit that looks like coffee grounds.

See also: Tiludronate side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Do not lie down. Symptoms may include heartburn; pain upon swallowing; stomach upset or pain; ulcers.

Proper storage of Tiludronate:

Store Tiludronate at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tiludronate out of the reach of children and away from pets.

General information:

If you have any questions about Tiludronate, please talk with your doctor, pharmacist, or other health care provider.

Tiludronate is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tiludronate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Tiludronate resources

Tiludronate Side Effects (in more detail)
Tiludronate Use in Pregnancy & Breastfeeding
Tiludronate Drug Interactions
Tiludronate Support Group
0 Reviews for Tiludronate - Add your own review/rating

tiludronate Advanced Consumer (Micromedex) - Includes Dosage Information

tiludronate Concise Consumer Information (Cerner Multum)

Skelid Prescribing Information (FDA)

Compare Tiludronate with other medications

Paget's Disease

Thursday, September 20, 2012

Sinus & Allergy PE

Generic Name: chlorpheniramine and phenylephrine (KLOR fen IR a meen and FEN il EFF rin)

Brand Names: Actifed Cold & Allergy, Allan Tannate Pediatric, Allerest PE, AlleRx, BP Allergy JR, C Phen, Cardec, Ceron, Chlor-Mes Jr, ChlorTan D, Cold & Allergy Relief, CP Dec, Dallergy Drops, Dallergy-JR, Dec-Chlorphen, Ed A-Hist, Ed ChlorPed D, Histadec, Nasohist Pediatric, NoHist, Ny-Tannic, PD-Hist D, PD-Hist D Drops, PediaTan D, Phenchlor Tannate Pediatric, R-Tanna, Relera, Rinate Pediatric, Rondec, Rondex, Rynatan, Rynatan Pediatric, Sildec-PE, Sinus & Allergy Maximum Strength, Sinus & Allergy PE, Sonahist, Sudafed PE Sinus & Allergy, Tanahist-D, Triaminic Cold & Allergy

What is Sinus & Allergy PE (chlorpheniramine and phenylephrine)?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine and phenylephrine is used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes.

Chlorpheniramine and phenylephrine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Sinus & Allergy PE (chlorpheniramine and phenylephrine)?

There are many brands and forms of this medication available and not all brands are listed on this leaflet.

Do not use chlorpheniramine and phenylephrine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You should not use this medication if you are allergic to chlorpheniramine or phenylephrine, or if you have severe high blood pressure or coronary artery disease, narrow-angle glaucoma, a stomach ulcer, or if you are unable to urinate.

Do not use this medication during an asthma attack.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine and phenylephrine. Older adults may be more likely to have side effects from this medicine. Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

What should I discuss with my healthcare provider before taking Sinus & Allergy PE (chlorpheniramine and phenylephrine)?

severe or uncontrolled high blood pressure;

severe coronary artery disease;

narrow angle glaucoma;

a stomach ulcer;

if you are unable to urinate; or

if you are having an asthma attack.

Ask a doctor or pharmacist if it is safe for you to take this medication if you have:

kidney disease;

liver disease;

diabetes;

glaucoma;

circulation problems;

heart disease or high blood pressure;

overactive thyroid;

a seizure disorder such as epilepsy;

asthma, emphysema or chronic bronchitis; or

urination problems or an enlarged prostate.

It is not known whether chlorpheniramine and phenylephrine is harmful to an unborn baby. Do not take this medication with a doctor's advice if you are pregnant. It is not known whether chlorpheniramine and phenylephrine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medicine.

Artificially sweetened liquid cold medicine may contain phenylalanine. If you have phenylketonuria (PKU), check the medication label to see if the product contains phenylalanine.

How should I take Sinus & Allergy PE (chlorpheniramine and phenylephrine)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

The chewable tablet must be chewed before swallowing.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

This medication can cause unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

If you need surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since cold medicine is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include some of the serious side effects listed in this medication guide.

What should I avoid while taking Sinus & Allergy PE (chlorpheniramine and phenylephrine)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine and phenylephrine. Ask a doctor or pharmacist before using any other cold, allergy, or sleep medicine. Chlorpheniramine and phenylephrine are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or decongestant.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Sinus & Allergy PE (chlorpheniramine and phenylephrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

fast or pounding heartbeats;

confusion, hallucinations, unusual thoughts or behavior;

severe dizziness, anxiety, restless feeling, nervousness;

urinating less than usual or not at all;

easy bruising or bleeding, unusual weakness; or

seizure (black-out or convulsions).

Less serious side effects may include:

blurred vision;

dry nose or mouth;

nausea, stomach pain, constipation, loss of appetite;

dizziness, drowsiness;

problems with memory or concentration;

ringing in your ears; or

feeling restless or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 800 FDA 1088.

What other drugs will affect Sinus & Allergy PE (chlorpheniramine and phenylephrine)?

Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine.

Tell your doctor about all other medications you use, especially:

mecamylamine (Inversine);

methyldopa (Aldomet);

reserpine;

a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;

a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton); or

an antidepressant such as amitriptyline (Elavil, Vanatrip), doxepin (Sinequan), nortriptyline (Pamelor), and others.

This list is not complete and other drugs may interact with chlorpheniramine and phenylephrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Sinus & Allergy PE resources

Sinus & Allergy PE Side Effects (in more detail)
Sinus & Allergy PE Use in Pregnancy & Breastfeeding
Sinus & Allergy PE Drug Interactions
Sinus & Allergy PE Support Group
0 Reviews for Sinus & Allergy PE - Add your own review/rating

AlleRx Suspension MedFacts Consumer Leaflet (Wolters Kluwer)

Cardec Drops MedFacts Consumer Leaflet (Wolters Kluwer)

Dallergy-JR Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

Ny-Tannic MedFacts Consumer Leaflet (Wolters Kluwer)

Relera Controlled-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

Rondec MedFacts Consumer Leaflet (Wolters Kluwer)

Rynatan Prescribing Information (FDA)

Sonahist Prescribing Information (FDA)

Compare Sinus & Allergy PE with other medications

Cold Symptoms
Hay Fever

Where can I get more information?

Your pharmacist can provide more information about chlorpheniramine and phenylephrine.

See also: Sinus & Allergy PE side effects (in more detail)

Tuesday, September 18, 2012

Tums 500

Generic Name: calcium carbonate (KAL see um KAR boe nate)

Brand Names: Alka-Mints, Cal-Gest, Calcarb, Calci Mix, Calci-Chew, Calci-Mix, Calcium Concentrate, Calcium Liquid Softgel, Calcium Oyster Shell, Caltrate, Chooz, Extra Strength Mylanta Calci Tabs, Icar Prenatal Chewable Calcium, Maalox Antacid Barrier, Maalox Childrens', Maalox Quick Dissolve, Maalox Quick Dissolve Maximum Strength, Maalox Regular Strength, Mylanta Child, Nephro Calci, Os-Cal 500, Oysco 500, Oyst Cal 500, Oyster Cal, Oyster Calcium, Oyster Shell, Pepto Children's, Rolaids Sodium Free, Rolaids Soft Chew, Titralac, Tums, Tums 500, Tums E-X, Tums Kids, Tums QuikPak, Tums Ultra

What is Tums 500 (calcium carbonate)?

Calcium is a mineral that is found naturally in foods. Calcium is necessary for many normal functions of the body, especially bone formation and maintenance. Calcium can also bind to other minerals (such as phosphate) and aid in their removal from the body.

Calcium carbonate is used to prevent and to treat calcium deficiencies.

Calcium carbonate may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Tums 500 (calcium carbonate)?

Do not take calcium carbonate or antacids that contain calcium without first asking your doctor if you also take other medicines. Calcium can make it harder for your body to absorb certain medicines. Calcium carbonate works best if you take it with food.

What should I discuss with my healthcare provider before taking Tums 500 (calcium carbonate)?

To make sure you can safely take calcium carbonate, tell your doctor if you have any of these other conditions:

a history of kidney stones; or

a parathyroid gland disorder.

Talk to your doctor before taking calcium carbonate if you are pregnant. Talk to your doctor before taking calcium carbonate if you are breast-feeding a baby.

How should I take Tums 500 (calcium carbonate)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Calcium carbonate works best if you take it with food. Swallow the calcium carbonate tablet or capsule with a full glass of water.

The chewable tablet should be chewed before you swallow it.

Use the calcium carbonate powder as directed. Allow the powder to dissolve completely, then consume the mixture.

Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, decreased appetite, constipation, confusion, delirium, stupor, and coma.

What should I avoid while taking Tums 500 (calcium carbonate)?

Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity.

Tums 500 (calcium carbonate) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

nausea or vomiting;

decreased appetite;

constipation;

dry mouth or increased thirst; or

urinating more than usual.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs can affect Tums 500 (calcium carbonate)?

Calcium carbonate can make it harder for your body to absorb other medications you take by mouth. Tell your doctor if you are taking:

digoxin (Lanoxin, Lanoxicaps);

antacids or other calcium supplements;

calcitriol (Rocaltrol) or vitamin D supplements; or

doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

This list is not complete and other drugs may interact with calcium carbonate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Tums 500 resources

Tums 500 Side Effects (in more detail)
Tums 500 Use in Pregnancy & Breastfeeding
Tums 500 Drug Interactions
Tums 500 Support Group
1 Review for Tums 500 - Add your own review/rating

Calcium Carbonate MedFacts Consumer Leaflet (Wolters Kluwer)

Titralac Consumer Overview

Titralac MedFacts Consumer Leaflet (Wolters Kluwer)

Tums Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Tums 500 with other medications

Duodenal Ulcer
Erosive Esophagitis
GERD
Indigestion
Stomach Ulcer

Where can I get more information?

Your doctor or pharmacist can provide more information about calcium carbonate.

See also: Tums 500 side effects (in more detail)

Sunday, September 16, 2012

Keralyt

Generic Name: salicylic acid topical (SAL i SIL ik AS id TOP ik al)

Brand Names: Compound W, DermalZone, Dermarest Psoriasis Skin Treatment, Dr Scholl's Callus Removers, Dr Scholl's Clear Away Wart Remover, Dr Scholl's Corn Removers, Duofilm, Freezone Corn Remover, Hydrisalic, Keralyt, Mediplast, Oxy Face Scrub, Propa P.H., Salac, Salex, Scalpicin Scalp Relief, Sebucare, Stri-Dex, Wart-Off Treatment

What is Keralyt (salicylic acid topical)?

Salicylic acid is a keratolytic (peeling agent). Salicylic acid causes shedding of the outer layer of skin.

Salicylic acid topical is used in the treatment of acne, dandruff, corns, and warts.

Salicylic acid topical may also be used for purposes other than those listed here.

What is the most important information I should know about Keralyt (salicylic acid topical)?

Avoid the eyes, mouth, lips, inside the nose, genitals, and anal areas when applying salicylic acid topical. Do not use the wart remover on moles or birthmarks, or warts with hair growing from them, red edges, or unusual color. Also, do not use salicylic acid topical on sunburned, windburned, dry, chapped, irritated, or broken skin; or on open wounds. If medication is applied to any of these areas, wash with water.

What should I discuss with my healthcare provider before using Keralyt (salicylic acid topical)?

Before using salicylic topical, talk to your doctor if you

have kidney disease;

have liver disease;

have diabetes;

have poor circulation; or

are treating a child.

You may not be able to use salicylic acid topical, or you may require a dosage adjustment or special monitoring during treatment.

It is not known whether salicylic acid topical will be harmful to an unborn baby. Do not use salicylic acid topical without first talking to your doctor if you are pregnant or could become pregnant during treatment. Salicylic acid topical may pass into breast milk and affect a nursing baby. Do not use salicylic acid topical without first talking to your doctor if you are breast-feeding a baby.

How should I use Keralyt (salicylic acid topical)?

Use salicylic acid topical exactly as directed by your healthcare provider or as directed on the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Gently clean and dry the affected area. For the treatment of warts and calluses, gentle removal of loose skin with a soft brush, wash cloth, or emery board may be recommended before application of the medication.

Shake the lotion gently before application.

Apply a thin film of the medication to the affected area(s) as directed.

Use the soap and shampoo as directed on the package.

Apply the salicylic acid topical adhesive pads as directed on the package.

It is important to use salicylic acid topical regularly to get the most benefit. Do not stop using the medication if you do not see results immediately. Use the medication for the full amount of time directed.

Talk to your doctor if you experience excessive burning, dryness, or irritation of the skin, or changes in the color of the skin.

Store salicylic acid topical at room temperature away from moisture and heat. Some forms of salicylic acid topical may be flammable, keep away from heat and flame.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and use only the next regularly scheduled dose.

Do not apply a double dose of the medication.

What happens if I overdose?

An overdose of salicylic acid topical is unlikely to occur. If you do suspect an overdose, or if the medication has been ingested, call a poison control center or emergency room for advice.

What should I avoid while using Keralyt (salicylic acid topical)?

Do not use other topical preparations on the treated area unless otherwise directed by your healthcare provider. They may interfere with treatment or increase skin irritation.

Avoid the use of abrasive, harsh, or drying soaps and cleansers such as alcoholic cleansers, tinctures, astringents, abrasives, or other peeling agents while using salicylic acid topical.

Keralyt (salicylic acid topical) side effects

Serious side effects are not likely to occur with the use of salicylic acid topical. If you do experience any of the following rare serious side effects, stop using salicylic acid topical and seek emergency medical attention or contact your doctor:

an allergic reaction (shortness of breath; closing of the throat; swelling of the lips, face, or tongue; or hives); or

severe skin irritation.

Other, less serious side effects are more likely to occur. Continue to use salicylic acid topical and talk to your doctor if you experience skin burning; stinging; itching; dryness; redness; peeling; or irritation.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Keralyt (salicylic acid topical)?

Do not use other topical preparations on the treated area unless otherwise directed by your healthcare provider. They may interfere with treatment or increase skin irritation.

Avoid the use of abrasive, harsh, or drying soaps and cleansers such as alcoholic cleansers, tinctures, astringents, abrasives, or other peeling agents while using salicylic acid topical.

Drugs other than those listed here may also interact with salicylic acid topical. Talk to your doctor and pharmacist before taking or using any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

More Keralyt resources

Keralyt Side Effects (in more detail)
Keralyt Use in Pregnancy & Breastfeeding
Keralyt Drug Interactions
Keralyt Support Group
0 Reviews for Keralyt - Add your own review/rating

Keralyt Topical Advanced Consumer (Micromedex) - Includes Dosage Information

Keralyt Prescribing Information (FDA)

Keralyt Gel MedFacts Consumer Leaflet (Wolters Kluwer)

Duofilm Solution MedFacts Consumer Leaflet (Wolters Kluwer)

Duoplant Gel MedFacts Consumer Leaflet (Wolters Kluwer)

Durasal Prescribing Information (FDA)

Freezone Liquid MedFacts Consumer Leaflet (Wolters Kluwer)

Hydrisalic Gel MedFacts Consumer Leaflet (Wolters Kluwer)

Ionil Plus Shampoo MedFacts Consumer Leaflet (Wolters Kluwer)

Keralyt Scalp Shampoo MedFacts Consumer Leaflet (Wolters Kluwer)

Salacyn Lotion MedFacts Consumer Leaflet (Wolters Kluwer)

Salex Prescribing Information (FDA)

Salex Lotion MedFacts Consumer Leaflet (Wolters Kluwer)

Salkera Foam MedFacts Consumer Leaflet (Wolters Kluwer)

Salvax Prescribing Information (FDA)

Virasal Prescribing Information (FDA)

Virasal Film-Forming Liquid MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Keralyt with other medications

Acne
Dermatological Disorders

Where can I get more information?

Your pharmacist has additional information about salicylic acid topical written for health professionals that you may read.

See also: Keralyt side effects (in more detail)

Saturday, September 15, 2012

Sulfatrim Pediatric

Generic Name: sulfamethoxazole/trimethoprim (Oral route)

sul-fa-meth-OX-a-zole, trye-METH-oh-prim

Commonly used brand name(s)

In the U.S.

Bactrim

Bactrim DS

Septra

Septra DS

Sulfatrim

Sulfatrim Pediatric

In Canada

Apo-Sulfatrim

Novo-Trimel

Nu-Cotrimox

Septa Pediatric

Septra Pediatric Suspension

Available Dosage Forms:

Tablet

Suspension

Therapeutic Class: Sulfonamide Combination

Pharmacologic Class: Folic Acid Antagonist

Chemical Class: Sulfonamide

Uses For Sulfatrim Pediatric

Sulfamethoxazole and trimethoprim combination is used to treat infections such as urinary tract infections, middle ear infections (otitis media), bronchitis, traveler's diarrhea, and shigellosis (bacillary dysentery). This medicine is also used to prevent or treat Pneumocystis carinii pneumonia (PCP), a very serious kind of pneumonia. This type of pneumonia occurs more commonly in patients whose immune systems are not working normally, such as cancer patients, transplant patients, and patients with acquired immune deficiency syndrome (AIDS).

Sulfamethoxazole and trimethoprim combination is an antibiotic. It works by eliminating the bacteria that cause many kinds of infections. This medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Before Using Sulfatrim Pediatric

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of sulfamethoxazole and trimethoprim combination in children and infants 2 months of age and older. Because of the toxicity of the combination of sulfamethoxazole and trimethoprim, use in infants younger than 2 months of age is not recommended.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sulfamethoxazole and trimethoprim combination in the elderly. However, elderly patients are more likely to have a folate deficiency, age-related kidney or liver problems, and may be more likely to experience unwanted side effects (e.g., severe skin rash, increased potassium in the body, or problems with blood clotting or the immune system). There may be a dose adjustment for elderly patients receiving sulfamethoxazole and trimethoprim combination.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Sulfamethoxazole

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Trimethoprim

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Bepridil

Cisapride

Dofetilide

Levomethadyl

Mesoridazine

Pimozide

Terfenadine

Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acecainide

Acenocoumarol

Ajmaline

Amiodarone

Amisulpride

Amitriptyline

Amoxapine

Aprindine

Arsenic Trioxide

Astemizole

Azimilide

Bretylium

Chloral Hydrate

Chloroquine

Chlorpromazine

Clarithromycin

Desipramine

Dibenzepin

Disopyramide

Dolasetron

Doxepin

Droperidol

Eltrombopag

Enflurane

Erythromycin

Flecainide

Fluconazole

Fluoxetine

Foscarnet

Gemifloxacin

Halofantrine

Haloperidol

Halothane

Hydroquinidine

Ibutilide

Imipramine

Isoflurane

Isradipine

Lidoflazine

Lorcainide

Mefloquine

Methotrexate

Nortriptyline

Octreotide

Pentamidine

Pirmenol

Prajmaline

Probucol

Procainamide

Prochlorperazine

Propafenone

Pyrimethamine

Quetiapine

Quinidine

Risperidone

Sematilide

Sertindole

Sotalol

Spiramycin

Sultopride

Tedisamil

Telithromycin

Trifluoperazine

Trimipramine

Vasopressin

Warfarin

Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acetohexamide

Anisindione

Chlorpropamide

Didanosine

Digoxin

Enalaprilat

Enalapril Maleate

Fosphenytoin

Glipizide

Glyburide

Phenytoin

Quinapril

Repaglinide

Rifabutin

Rosiglitazone

Tolazamide

Tolbutamide

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Proper Use of trimethoprim and sulfamethoxazole

This section provides information on the proper use of a number of products that contain trimethoprim and sulfamethoxazole. It may not be specific to Sulfatrim Pediatric. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Sulfamethoxazole and trimethoprim combination is best taken with a full glass (8 ounces) of water. Several additional glasses of water should be taken every day, unless otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects. .

For patients taking the oral liquid, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (liquid or tablets):
- For treatment of bacterial infections:
  - Adults and children weighing 40 kilograms (kg) or more—800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim every 12 hours. Your doctor may adjust this dose if needed.
  - Children and infants 2 months of age and older, and weighing up to 40 kg—Dose is based on body weight and must be determined by your doctor. The usual dose is 40 milligrams (mg) of sulfamethoxazole and 8 milligrams (mg) of trimethoprim per kilogram of body weight, given in two divided doses every 12 hours.
  - Infants younger than 2 months of age—Use is not recommended.
- For chronic bronchitis:
  - Adults—800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim every 12 hours. Your doctor may adjust this dose if needed.
  - Children and infants 2 months of age and older—Use and dose must be determined by your doctor.
  - Infants younger than 2 months of age—Use is not recommended.
- For treatment of Pneumocystis carinii pneumonia (PCP):
  - Adults and children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 75 to 100 milligrams (mg) of sulfamethoxazole and 15 to 20 milligrams (mg) of trimethoprim per kilogram of body weight each day, given in equally divided doses every 6 hours.
  - Infants younger than 2 months of age—Use is not recommended.
- For prevention of Pneumocystis carinii pneumonia (PCP):
  - Adults—800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim once a day. Your doctor may adjust this dose if needed.
  - Children and infants 2 months of age and older—Dose is based on body size and must be determined by your doctor. The dose is 750 mg of sulfamethoxazole and 150 mg of trimethoprim per square meter (m[2]) of body surface each day. This is given in equally divided doses two times a day for 3 days a week on consecutive days (e.g., Monday, Tuesday, Wednesday).
  - Infants younger than 2 months of age—Use is not recommended.
- For traveler's diarrhea:
  - Adults—800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim every 12 hours. Your doctor may adjust this dose if needed.
  - Children and infants 2 months of age and older—Use and dose must be determined by your doctor.
  - Infants younger than 2 months of age—Use is not recommended.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Sulfatrim Pediatric

It is very important that your doctor check the progress of you or your child at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Very rarely, this medicine has caused severe side effects. If you or your child start to have a skin rash, or if you think you are having a severe skin reaction, stop taking this medicine and call your doctor right away. Symptoms of a severe reaction may include a skin rash, skin color that is very pale or yellow, or skin with purple spots, along with a sore throat, fever, muscle pain, cough, and trouble with breathing.

This medicine, especially if you are receiving high doses or for a long period of time, may lower the number of platelets in your body, which are necessary for proper blood clotting. Because of this, you may bleed or get infections more easily. Talk with your doctor if you have concerns about this.

This medicine may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop taking this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

Check with your doctor right away if you or your child have abdominal or stomach cramps; bloating; watery and severe diarrhea, which may also be bloody; nausea or vomiting; or unusual tiredness or weakness. These may be symptoms of a serious intestinal infection.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Check with your doctor right away if you or your child have a rash; itching; swelling of the face, tongue, and throat; trouble with breathing; shortness of breath; or chest pain after you use the medicine.

Before you have any medical tests, tell the medical doctor in charge that you or your child are taking this medicine. The results of some tests may be affected by this medicine.

Patients receiving anticonvulsant therapy (medicines to prevent seizures) may be at risk for a folate (vitamin B9) deficiency, which may increase the risk for side effects. Talk with your doctor if you have concerns about this.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Sulfatrim Pediatric Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Abdominal or stomach pain

black, tarry stools

blistering, peeling, or loosening of the skin

changes in skin color

chest pain

chills

cough or hoarseness

dark urine

diarrhea

dizziness

fever with or without chills

general feeling of tiredness or weakness

headache

itching

joint or muscle pain

light-colored stools

loss of appetite

lower back or side pain

nausea

pain, tenderness, or swelling of the foot or leg

painful or difficult urination

pale skin

rash

red irritated eyes

red skin lesions, often with a purple center

shortness of breath

sore throat

sores, ulcers, or white spots in the mouth or on the lips

swollen or painful glands

tightness in the chest

unpleasant breath odor

unusual bleeding or bruising

vomiting of blood

wheezing

yellow eyes or skin

Incidence not known

Abdominal or stomach tenderness

back, leg, or stomach pains

bleeding gums

blindness or vision changes

blisters, hives, or itching

bloating

blood in the urine or stools

bluish-colored lips, fingernails, or palms

burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings

burning of the face or mouth

chest pain

cloudy urine

confusion

constipation

continuing ringing or buzzing or other unexplained noise in the ears

convulsions

cracks in the skin

decreased frequency or amount of urine

diarrhea, watery and severe, which may also be bloody

difficulty with breathing

difficulty with swallowing

fainting spells

general body swelling

general feeling of discomfort or illness

hair loss

hearing loss

hives

increased blood pressure

increased thirst

indigestion

irregular heartbeat

large, flat, blue, or purplish patches in the skin

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

loss of heat from the body

muscle or joint pain

nosebleeds

not able to pass urine

numbness or tingling in the hands, feet, or lips

pain or burning while urinating

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

raised red swellings on the skin, the buttocks, legs, or ankles

redness of the white part of the eyes

redness, swelling, or soreness of the tongue

sores, ulcers, or white spots on the lips or in the mouth

soreness of the muscles

stiff neck or back

swelling of the face, hands, legs, and feet

unsteadiness, trembling, or other problems with muscle control or coordination

unusual weight loss

weakness in the hands or feet

weakness or heaviness of the legs

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Passing of gas

Incidence not known

Discouragement

feeling of constant movement of self or surroundings

feeling sad or empty

increased sensitivity of skin to sunlight

irritability

lack of feeling or emotion

loss of interest or pleasure

nervousness

redness or other discoloration of the skin

seeing, hearing, or feeling things that are not there

sensation of spinning

severe sunburn

sleeplessness

trouble concentrating

trouble sleeping

unable to sleep

uncaring

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Sulfatrim Pediatric side effects (in more detail)

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More Sulfatrim Pediatric resources

Sulfatrim Pediatric Side Effects (in more detail)
Sulfatrim Pediatric Use in Pregnancy & Breastfeeding
Sulfatrim Pediatric Drug Interactions
Sulfatrim Pediatric Support Group
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Septra Prescribing Information (FDA)

Sulfatrim Suspension MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Sulfatrim Pediatric with other medications

Bacterial Infection
Bacterial Skin Infection
Bronchitis
Diverticulitis
Epiglottitis
Granuloma Inguinale
Infection Prophylaxis
Kidney Infections
Melioidosis
Meningitis
Nocardiosis
Otitis Media
Pneumocystis Pneumonia
Pneumocystis Pneumonia Prophylaxis
Pneumonia
Prevention of Bladder infection
Prostatitis
Shigellosis
Sinusitis
Toxoplasmosis
Toxoplasmosis, Prophylaxis
Traveler's Diarrhea
Upper Respiratory Tract Infection
Urinary Tract Infection